New research in mice suggests that adding a certain type of tomato concentrate to the diet can reduce the intestinal inflammation that is associated with HIV. Left untreated, intestinal inflammation can accelerate arterial disease, which in turn can lead to heart attack and stroke. The findings provide clues to how the altered intestinal tract affects…

The use of antipsychotics in young children is declining but doctors continue to prescribe these medications off-label for conditions not approved by the Food and Drug Administration and without the recommended psychiatric consultation, a new study found. The study, published in the Journal of the American Academy of Child and Adolescent Psychiatry, looked at 301,311…

New basic science and clinical research identifies TAU, the same protein studied in the development of Alzheimer’s, as a biomarker for glioma development. The new study, in mouse models and human brain tumor tissues, was published in Science Translational Medicine and found a significant expression of the protein TAU in glioma cells, especially in those…

Researchers worked to determine whether vibration training — an intervention used to improve physical function for people with multiple sclerosis — could also improve patients’ cognitive function and quality of life. Cognitive impairment has been particularly difficult for researchers to address, with few intervention strategies proven effective in preserving or restoring cognitive functions for people…

Physical fitness is associated with a number of key health outcomes, including heart disease, cognition, mortality, and an overall feeling of well-being. A new study now links physical performance with mental health and emotions, suggesting that weak upper and lower body fitness can cause more serious depression and anxiety in midlife women. Although several studies…

There are myriad reasons why cancers develop. By studying genes which are altered in people with lymphoma, a multidisciplinary team of researchers has identified a key mechanism involved in disease development. This signaling pathway, which the researchers describe in detail, controls the repair of DNA damage. Cancer is associated with the disruption of various cellular…

Proteins classically associated with autophagy regulate the speed of intracellular transport. Autophagy cleans the cells by breaking down and removing the damaged proteins and organelles, cell areas with a specific function. It is hardly surprising that this process is particularly important for long-lived cells such as neurons, since neurons are no longer capable of cell…

Scientists modify CAR T-Cell therapy, making it more effective and less toxic, for possible use in solid tumors such as neuroblastoma. Shahab Asgharzadeh, MD, a physician scientist at the Cancer and Blood Disease Institute of CHLA, is working to improve the lifesaving CAR T-cell therapy, in which scientists take a patient’s own immune system T-cells…

New evidence published in the Cochrane Library provides high quality evidence that people who use a combination of nicotine replacement therapies (a patch plus a short acting form, such as gum or lozenge) are more likely to successfully quit smoking than people who use a single form of the medicine. Nicotine replacement therapy (NRT) is…

Good sleep-time recovery is associated with a health-promoting diet and health-promoting eating habits, as well as with lower consumption of alcohol, according to a new study investigating psychological and physiological well-being among working-age Finnish adults. The association of physiological recovery with nutrition has been studied only scarcely. Published in Journal of Occupational Medicine and Toxicology,…