A new study of over 3000 people, has shown for the first time that a single biomarker can accurately indicate the presence of underlying neurodegeneration in people with cognitive issues. Published in Nature Communications and part-funded by the NIHR Maudsley Biomedical Research Centre, the research determined a set of age-related cut-off levels of NfL which…

A new study found that one in three young adults receive medication for opioid use disorder within 12 months of a non-fatal opioid overdose. The study shows which medications — buprenorphine, methadone or naltrexone — are being taken, and how long after the overdose they receive the treatment. Nonfatal opioid overdose is a significant predictor…

Researchers find an increase in inflammatory molecules in serum and cerebrospinal fluid of C90RF72 patients, informing future anti-inflammatory therapies. In comprehensive analyses, the researchers collected cerebrospinal fluid (CSF), via a small puncture in the spine, as well as serum from 15 C9orf72 patients, 9 sporadic ALS patients and 14 control patients, and conducted a test…

The treatment of cancer could be revolutionized by the discovery that existing drugs, used to treat depression and heart disease, could reverse key changes in cancer cells that are associated with their ability to spread. Cancer starts when certain changes take place within the genes inside the nucleus of a cell — the cell’s command…

People with diabetes and depression who take antidepressants may have a lower risk of death and of serious diabetes complications, according to a new study. People with diabetes face a higher risk of depression, which makes them more likely to die or develop diabetes complications including heart and kidney disease, stroke, eye, and foot problems.…

A new study investigates subthreshold depression, a more severe form of depression that includes not only sad mood, but also some of the other symptoms of depression, and reports that psychological interventions may have a modest, but significant effect on the treatment of this type of depression in adolescents. Characterized by clinically relevant symptoms that…

Lab-grown brain organoids developed from a patient’s own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study showed how glioblastoma organoids could serve as effective models to rapidly test personalized treatment strategies. Glioblastoma multiforme (GBM) remains the most difficult of all…

Puerto Rican teens growing up as minorities in the South Bronx are more likely to experience anxiety and depression than their peers growing up as a majority in Puerto Rico, even under similar conditions of poverty. «How others interact with you as a minority can affect your mental health and how you see yourself. The…

A new study details the first comprehensive look across the scientific literature at the role of mind-body therapies in addressing opioid-treated pain. The researchers found that certain mind-body therapies can reduce pain, as well as reduce opioid use, among patients treated with prescription opioids. «These findings are critical for medical and behavioral health professionals as…

Scientists have identified a novel target for a type of pediatric brain tumor. Medulloblastoma is the most common malignant pediatric brain tumor. There are four genomic subgroups of the disease: WNT, SHH, Group 3 and Group 4. The SHH subgroup accounts for about 25% of all pediatric medulloblastoma cases. The five-year survival rate for SHH…