We all have an internal clock but what makes us tick? Scientists have developed new artificial intelligence (AI) and machine learning (ML) technology to understand how gene expression regulates an organism’s circadian clock.

Circadian rhythms, such as the sleep-wake cycle, are innate to most living organisms and critical to life on Earth. The word circadian originates from the Latin phrase ‘circa diem’ which means ‘around a day’.

Biologically, the circadian clock temporally orchestrates physiology, biochemistry, and metabolism across the 24-hour day-night cycle. This is why being out of kilter can affect our fitness levels, our health, or our ability to survive. For example, experiencing jet lag is a chronobiological problem — our body clocks are out of sync because the normal external cues such as light or temperature have changed.

The circadian clock isn’t unique to humans. In plants, an accurate clock helps to regulate flowering and is crucial to synchronising metabolism and physiology with the rising and setting sun. Understanding circadian rhythms can help to improve plant growth and yields, not to mention revealing new avenues for tackling human diseases.

Beyond plants

For this latest research, the team applied ML to predict complex temporal circadian gene expression patterns in model plant Arabidopsis thaliana. Taking newly generated datasets, published temporal datasets, and Arabidopsis genomes, the team of scientists trained ML models to make predictions about circadian gene regulation and expression patterns.

Story Source: Materials provided by Earlham Institute. Note: Content may be edited for style and length.