A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans — including SARS-CoV-2, the cause of COVID-19 — may be possible, say researchers.
In a paper posted online Jan. 21, 2022, in the Journal of Clinical Investigation, the research team focused on a peptide, or protein fragment, on the SARS-CoV-2 spike protein — the target of the two available messenger RNA (mRNA) vaccines for COVID-19 — called S815-827. Homologs (equivalent peptides) can be found on the spike proteins of MERS-CoV (the virus that causes Middle East Respiratory Syndrome, more commonly known as MERS, and believed to have been passed from camels to humans) and other animal coronaviruses. The researchers were particularly interested in studying the S815-827 homologs seen in coronaviruses hosted by bats because SARS-CoV-2 is believed to have risen from a bat species. Additionally, bat-borne coronaviruses are considered a major threat for producing future zoonotic (animal-to-human) diseases.
Previous research studies looking at a variety of human coronaviruses that cause the common cold have shown that homologs of the S815-827 peptide — also known as an epitope (a protein or portion of a protein that elicits an immune response) — are recognized by infection-fighting cells of the immune system called CD4+ T lymphocytes.
In the first part of their study, the Johns Hopkins Medicine researchers evaluated T cell response to the S815-827 epitope in 38 people who had received two doses of either the Moderna or Pfizer-BioNTech mRNA vaccines against SARS-CoV-2. They found that T cells specific to the peptide were produced by 16 (42%) of the study participants.
«This suggests that a significant portion of the vaccinated population might have T cells that produce an immune response to the epitope,» says study senior author Joel Blankson, M.D., Ph.D., professor of medicine at the Johns Hopkins University School of Medicine. «Since this particular spike protein component is believed to have an important functional role in SARS-CoV-2 infections and is considered less likely to change because of mutations, it’s an appealing target for future vaccines — especially if it also can protect against animal coronaviruses that might migrate to humans.»
CD4+ T lymphocytes are immune system cells, also known as helper T cells, because they assist another type of immune cell, the B lymphocyte (B cell), in responding to surface proteins — antigens — on viruses such as SARS-CoV-2. Activated by the CD4+ T cells, immature B cells become either plasma cells that produce antibodies to mark infected cells for disposal from the body, or memory cells that «remember» the antigen’s biochemical structure for a faster response to future infections. Therefore, a CD4+ T cell response can serve as a measure of how well the immune system responds to a vaccine and yields humoral immunity.
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Materials provided by Johns Hopkins Medicine. Note: Content may be edited for style and length.